Latrunculin with a Highly Oxidized Thiazolidinone Ring: Structure Assignment and Actin Docking
نویسندگان
چکیده
منابع مشابه
Actin-latrunculin A structure and function. Differential modulation of actin-binding protein function by latrunculin A.
Latrunculin A is used extensively as an agent to sequester monomeric actin in living cells. We hypothesize that additional activities of latrunculin A may be important for its biological activity. Our data are consistent with the formation of a 1:1 stoichiometric complex with an equilibrium dissociation constant of 0.2 to 0.4 micrometer and provide no evidence that the actin-latrunculin A compl...
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Deliberate digression from the blueprint of the total syntheses of latrunculin A (1) and latrunculin B (2) reported in the accompanying paper allowed for the preparation of a focused library of "latrunculin-like" compounds, in which all characteristic structural elements of these macrolides were subject to pertinent molecular editing. Although all previously reported derivatives of 1 and 2 were...
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ژورنال
عنوان ژورنال: Organic Letters
سال: 2007
ISSN: 1523-7060,1523-7052
DOI: 10.1021/ol7020675